New-Generation Enhanced Antibody and Vaccines comprises several novel classes of monoclonal antibodies and vaccines invented at the Massachusetts General Hospital. These antibodies are being developed mainly for oncology and infectious diseases. Scientists at MGH have designed and created an anti-cancer therapeutic platform by fusing specific small chain variable fragments (scFv) of monoclonal antibodies (mAbs) to recombinant forms of heat shock protein 70, a protein that plays an important role in the immune system. These novel molecules, which we call Jantibodies, constitute a new generation of highly immunogenic mAbs against cancer and other diseases. The scFv portion of the fusion construct attaches to the target on the tumor cell while the HSP70 portion triggers an immune response that is anticipated to be highly effective in treating solid tumor cancers. Jantibodies can be formed either with Mycobacterium tuberculosis heat shock protein 70 (MTB HSP70), which elicits both an innate immune and a cell-mediated immune response in humans, or human heat shock protein 70 (hu HSP70), which produces a more nuanced cell-mediated immune response. The same scientific team has created a class of "self-assembling vaccines", in which HSP 70 fusions self-assemble with targets, which could be whole cells, antigens, or antibody fragments. This makes personalized cancer vaccines rapid and practical to generate, and enables rapid responses for infections as well.

Boston BioCom has formed a new company, Jantibody Therapeutics, LLC, to develop both approaches for application to a broad range of cancers. The company has enormous competitive advantage in the area due to its collaborations with world-leading cancer immunologists and the use of proprietary Russian technology. The products of this technology will be novel therapeutic antibodies and vaccines applicable to different types of cancer. Both types of technologies are covered by the intellectual property licensed from Massachusetts General Hospital and from a Russian company.